A New Role for Nuclear Transport Factor 2 and Ran: Nuclear Import of CapG
نویسندگان
چکیده
منابع مشابه
Identification and characterization of the Arabidopsis orthologs of nuclear transport factor 2, the nuclear import factor of ran.
Ran is a multifunctional small GTPase that is involved in nucleocytoplasmic transport, mitotic spindle assembly, and nuclear envelope formation. Nuclear import of Ran relies on a small RanGDP-binding protein, Nuclear Transport Factor 2 (NTF2). Three proteins are expressed in Arabidopsis (Arabidopsis thaliana) that show significant sequence similarity to human and yeast (Saccharomyces cerevisiae...
متن کاملNTF2 mediates nuclear import of Ran.
Importin beta family transport receptors shuttle between the nucleus and the cytoplasm and mediate transport of macromolecules through nuclear pore complexes (NPCs). The interactions between these receptors and their cargoes are regulated by binding RanGTP; all receptors probably exit the nucleus complexed with RanGTP, and so should deplete RanGTP continuously from the nucleus. We describe here...
متن کاملNuclear import of Ran is mediated by the transport factor NTF2
A concentration gradient of the GTP-bound form of the GTPase Ran across nuclear pores is essential for the transport of many proteins and nucleic acids between the nuclear and cytoplasmic compartments of eukaryotic cells [1] [2] [3] [4]. The mechanisms responsible for the dynamics and maintenance of this Ran gradient have been unclear. We now show that Ran shuttles between the nucleosol and cyt...
متن کاملModeling and simulation of Ran-mediated nuclear import
We present here a detailed description of the model of ran-driven nuclear transduction in living cells to be published in [9]. The mathematical model presented is the first to account for the active transport of molecules along the cytoplasmic microtubules. All parameters entering the models are thoroughly discussed. The simulations, carried out using the numerical scheme presented in [8], repr...
متن کاملNuclear Import of IkBa Is Accomplished by a Ran-Independent Transport Pathway
The inhibitor of kappa B alpha (IkBa) protein is able to shuttle between the cytoplasm and the nucleus. We have utilized a combination of in vivo and in vitro approaches to provide mechanistic insight into nucleocytoplasmic shuttling by IkBa. IkBa contains multiple functional domains that contribute to shuttling of IkBa between the cytoplasm and the nucleus. Nuclear import of IkBa is mediated b...
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ژورنال
عنوان ژورنال: Traffic
سال: 2008
ISSN: 1398-9219,1600-0854
DOI: 10.1111/j.1600-0854.2008.00720.x